Endocrine Abstracts

Objective: Parathyroidectomy (PTx) improves quality of life (QoL) in patients with primary hyperparathyroidism (PHPT). Whether this effect is modified according to the patients’ age is unknown. The aim of this study was to evaluate the impact of age on the effect of PTx on QoL and frailty in patients with PHPT, six months post-PTx. Methods: This was a prospective cohort study, including patients with PHPT, admitted from January 2016 to December 2019...

Introduction: Various methods to quantify calcified coronary plaque have been used in common clinical practice in the past few decades to compliment cardiovascular risk assessment. The estimation of calcium load in other organs and conditions has been at best semi-quantitative. Patients with long-standing hypoparathyroidism are known to suffer with nephrocalcinosis and basal ganglia calcification. We attempted to quantify end-organ calcium burden in a series of patients with v...

ContextWhether pre-operative vitamin D deficiency (VDD) contributes to post-operative hypoparathyroidism (hypoPT) risk is unknown.ObjectiveTo meta-analyze the best available evidence regarding the association between pre-operative vitamin D status and hypoPT risk.Data SourcesA comprehensive literature search was conducted in PubMed, CENTRAL and Scopus databases, u...

IntroductionPrimary hyperparathyroidism (PHPT) is characterized by excessive secretion of parathyroid hormone (PTH) from one or more parathyroid glands. PTH has a central role in the regulation of calcium and phosphate and the classic disorder causes primarily hypercalcemia associated with renal and bone manifestations. Non-classical symptoms are also present including cardiovascular, gastrointestinal, psychiatric, neuro-cognitive disorders. Regarding ca...